Blepharochalasis, a rare and often misunderstood eyelid disorder, can significantly impact an individual’s quality of life. This blog post will illuminate this uncommon condition, delving into the symptoms, causes, treatments, and prognosis. By the end of this comprehensive guide, you will have gained valuable insights into this intriguing disorder and the available management options.

Key Takeaways

  • Blepharochalasis is a rare disorder characterized by recurrent inflammation and thinning of the eyelids.
  • Diagnosis requires an extensive differential diagnosis to rule out other conditions, with treatment typically involving surgical interventions.
  • Surgical interventions can improve functional and cosmetic outcomes, while Research into potential triggers is necessary for more effective therapies.

Understanding Blepharochalasis

Image of an eyelid with skin swelling due to blepharochalasis

Blepharochalasis is a rare disorder, also known as blepharochalasis syndrome, marked by episodic inflammation of the eyelids, which can sometimes be related to idiopathic orbital inflammation. The condition affects both genders but is more prevalent in females during adolescence. Despite its rarity, the disorder can have a significant impact on an individual’s appearance and quality of life.

The progression of the disorder typically follows two stages, the active intumescent phase marked by recurrent episodes of eyelid swelling and the quiescent phase characterized by thin, wrinkled eyelid skin. As the eyelid skin gradually loses its elasticity, episodes of blepharochalasis affecting the upper eyelids generally recur every 3 to 4 months over a few years, with the frequency of occurrences decreasing as the patient ages.

Definition and Prevalence

An image showing a person with blepharochalasis, a medical condition characterized by the thinning and sagging of the eyelid skin.

Characterized by episodic eyelid inflammation, blepharochalasis is a rare condition that affects both genders, with a higher prevalence amongst adolescent females. The onset of blepharochalasis typically occurs around 11.4 years of age. This is the average found among those suffering from this illness. In some cases, the condition may be triggered by upper respiratory tract infections. Patients typically report more frequent attacks during adolescence or young adulthood, which can lead to the development of redundant skin on the eyelids.

Medical treatments for blepharochalasis are limited and often restricted, with some experimental therapies reported in the literature. Consequently, surgery is frequently the recommended course of action. The primary manifestations of blepharochalasis include painless eyelid swelling, erythema, and conjunctival injection.

Stages and Progression

Blepharochalasis progresses through two stages. The active intumescent phase involves recurrent episodes of eyelid swelling, and the quiescent phase is characterized by thin, wrinkled eyelid skin, often accompanied by excess skin. It is generally observed that episodes of blepharochalasis recur every 3 to 4 months over a few years, with the frequency of occurrences decreasing as the patient ages.

Surgery, typically scheduled during the quiescent phase, is the recommended treatment for blepharochalasis. Blepharoplasty, eyelid tightening, and canthal tendon reattachment are the surgical options performed during the quiescent phase for blepharochalasis, which aim to correct the changes in the eyelid tissues.

Symptoms and Physical Examination Findings

Image of an eyelid with edema and erythema due to blepharochalasis

Painless eyelid swelling, erythema, and conjunctival injection are the primary manifestations of blepharochalasis. These symptoms can lead to a range of complications affecting the periocular anatomy, such as:

  • dermatochalasis
  • thin and wrinkled skin, including eyelid skin laxity
  • ptosis
  • canthal disinsertion
  • pseudoepicanthal fold
  • lacrimal gland prolapses
  • lower lid laxity and malposition

Eyelid Edema and Erythema

Eyelid edema, or swelling of the eyelid, is a primary symptom of blepharochalasis and can be caused by an eyelid disorder, orbital disorders, or systemic disorders that cause generalized edema. In these cases, the affected eyelid tissue may become inflamed or damaged.

Erythema, another primary symptom, is an inflammation of the skin characterized by redness due to increased blood flow to the affected area. Erythema can be caused by sun exposure, allergies, and infection.

Conjunctival injection, a redness of the conjunctiva, is another primary symptom of blepharochalasis. The thin membrane lining the inner surface of the eyelids and the outer surface of the eye becomes red due to increased blood flow to the area.

Ptosis and Lacrimal Gland Prolapse

In addition to the primary symptoms, blepharochalasis is associated with:

  • Ptosis (drooping eyelids)
  • Lacrimal gland prolapse
  • Malformation of the canthal angle
  • Retraction of the lower eyelid

Ptosis is the most frequently observed deformity, followed by prolapse of the lacrimal gland, malformation of the canthal angle, and retraction of the lower eyelid.

These complications can result in a combination of functional and cosmetic issues for the patient, including vision obstruction, bagginess, and an aged appearance. Timely diagnosis and appropriate treatment can help alleviate these complications and improve the quality of life for individuals with blepharochalasis.

Causes and Risk Factors

Image of a person with genetic factors that can lead to blepharochalasis

While the underlying pathology of blepharochalasis remains under-explored, evidence suggests an immunopathogenic process. The key findings include:

  • Loss of elastic fibers of the dermis in skin biopsies of blepharochalasis patients
  • IgA immune-mediated reaction directed towards these fibers
  • Implication of metalloproteinases MMP-3 and MMP-9 in the pathogenesis

Possible triggers for blepharochalasis episodes could include:

  • Hormonal changes
  • Infections
  • Allergies
  • Physical or emotional stress

Although genetics or heredity may be considered risk factors, they do not directly cause the disorder.

Genetic Factors

Genetic factors are believed to play a role in the development of blepharochalasis, although the precise genes involved remain unidentified. Cases showing a familial pattern suggest that there may be a genetic component to the disorder. Available data indicate that the following genes are associated with blepharochalasis:

  • GSN
  • OSMR
  • MMP3
  • MMP9

However, it is not generally accepted that the disorder is inherited in a straightforward manner.

Although a genetic predisposition may be present, environmental and behavioral triggers can also play a role in the development and progression of blepharochalasis. Understanding these factors can help in formulating effective treatment strategies for individuals affected by the condition.

Environmental and Behavioral Triggers

Episodes of blepharochalasis could be triggered by:

  • Hormonal changes
  • Infections
  • Allergies
  • Physical or emotional stress

Hormonal changes, particularly during adolescence, can be linked to the onset of blepharochalasis episodes. Infections, such as upper respiratory tract infections, are also known to be associated with the disorder.

Allergens and physical or emotional stress can also initiate episodes of blepharochalasis. Recognizing and addressing these potential triggers can be an important part of managing the condition and minimizing the impact on the patient’s quality of life.

Diagnosis and Differential Diagnosis

Image of a person with environmental and behavioral triggers that can lead to blepharochalasis

Diagnosing blepharochalasis involves reviewing patient history, conducting a physical examination, and excluding other similar conditions.

Accurate diagnosis and effective treatment planning require a comprehensive differential diagnosis.

Diagnostic Criteria

Patient history, physical examination, and the exclusion of other conditions form the basis of blepharochalasis diagnosis. The diagnostic criteria for blepharochalasis are determined by the typical progression and examination of the condition during the active and inactive phases. An eye care specialist will examine the eyelids and eyes in order to diagnose blepharochalasis.

Since the results of supplementary tests in blepharochalasis are within the normal range, blood tests and imaging may be conducted largely to eliminate other conditions. Patient history and physical examination are pivotal to the diagnosis of blepharochalasis, providing critical information to identify the disorder accurately.

Ruling Out Other Conditions

Conditions that should be included in a differential diagnosis for blepharochalasis are:

  • Allergic reactions
  • Local eyelid infection/inflammation
  • Orbital inflammation
  • Skin conditions
  • Angioedema
  • Melkerson-Rosenthal Syndrome
  • Dermatochalasis
  • Floppy eyelid syndrome
  • Upper lid ptosis
  • Acquired cutis laxa
  • Eyelid/orbital masses

It is imperative to eliminate alternative conditions by constructing a comprehensive differential diagnosis.

Dermatochalasis, for example, is more commonly observed in older individuals and is characterized by lax or redundant upper eyelid skin, whereas blepharochalasis is characterized by features such as cigarette paper skin, relapsing and remitting edema, and subcutaneous telangiectasia. Accurate diagnosis is essential for determining the most appropriate treatment options for the patient.

Treatment Options for Blepharochalasis

Image of a person undergoing upper eyelid blepharoplasty to treat blepharochalasis

Blepharochalasis can be treated with a variety of medical and surgical options, even though the effectiveness of medical treatments is often limited.

In contrast, surgical treatment in the form of interventions can significantly enhance both functional and cosmetic outcomes for patients.

Medical Management

Current medical treatments for blepharochalasis are largely limited, though some experimental therapies have been reported. While oral doxycycline has been reported to help two patients with blepharochalasis, successful medical treatment is often restricted, and surgery is frequently recommended.

The limitations of medical treatment highlight the need for further research into novel therapies for blepharochalasis. Moreover, understanding the potential triggers for episodes can help in the development of more effective treatment strategies.

Surgical Interventions

Blepharoplasty, eyelid tightening, and canthal tendon reattachment are surgical options for blepharochalasis, typically performed during the quiescent phase. These surgical interventions aim to correct the changes in the eyelid tissues caused by the disorder.

The timing of surgery is critical, as it is generally advisable to delay surgical correction until the disease has become less frequent. Waiting for a period of six to twelve months prior to surgery ensures disease quiescence and reduces the risk of recurrence. When performed at the appropriate time, surgical interventions can significantly improve functional and cosmetic outcomes for patients with blepharochalasis.

Prognosis and Long-term Outcomes

Image of a person undergoing medical management to treat blepharochalasis

The well-documented natural history of blepharochalasis has shown various presentations regarding the number of swelling attacks and the duration of the early stage. Consequently, the number and severity of complications may vary amongst patients.

The effect of surgery on the likelihood of recurrences is also uncertain, highlighting the need for further research on long-term outcomes.

Recurrence Rates

With limited data available, the recurrence rate of blepharochalasis episodes post-treatment remains uncertain. In a study examining lacrimal gland prolapse, recurrence was observed in two (4.00%) patients at 29 and 36 months post-surgery. This uncertainty underscores the importance of carefully selecting the timing of surgical interventions and the need for further research to understand better the factors influencing recurrence rates.

Despite the uncertainty surrounding recurrence rates, surgical interventions have been shown to provide satisfactory aesthetic results with minimal risk of overcorrection and recurrence. Understanding the factors contributing to the recurrence of blepharochalasis episodes can help formulate more effective treatment strategies and improve patient outcomes.

Quality of Life

For patients with blepharochalasis, surgical interventions can significantly enhance both functional and cosmetic outcomes, improving their quality of life. For example, surgical interventions such as blepharoplasty may improve vision, peripheral vision, and overall quality of life.

By addressing the complications of blepharochalasis through timely diagnosis and appropriate treatment, individuals affected by the disorder can experience considerable improvements in their daily lives. This highlights the importance of continued research and advancements in the understanding and management of this rare condition.


In conclusion, blepharochalasis is a rare and complex eyelid disorder that can significantly impact an individual’s quality of life. Understanding the causes, symptoms, and treatment options is crucial for effectively managing the condition. Although medical treatment options are limited, surgical interventions have shown promising results in improving patients’ functional and cosmetic outcomes. By raising awareness and advancing research on this uncommon condition, we can improve the lives of those affected and contribute to a better understanding of the underlying causes and potential therapies.

Frequently Asked Questions

What causes blepharochalasis?

Blepharochalasis is a rare disorder, and the exact cause remains unknown. However, genetics or heredity may be associated with increased chances of developing it.

What is the difference between blepharochalasis and blepharitis?

Blepharochalasis is an inflammation that affects both eyelids, with an unknown cause. Blepharitis on the other hand, is a swelling that only affects the edges of your eyelids, and is caused by irritants.

How do you fix blepharochalasis?

Blepharochalasis episodes usually come and go for a few years, and there is no specific treatment. An eye care specialist may prescribe medications to reduce inflammation and swelling.

What is the difference between blepharochalasis and dermatochalasis?

Blepharochalasis is a surgical procedure that removes protruding fat and tightens the orbital septum. Whereas dermatochalasis is a surgical procedure that removes excess skin from the eyelids only.

What are examples of syndromes?

Examples of syndromes include chronic fatigue syndrome, irritable bowel syndrome, Asperger’s syndrome, Turner syndrome, and Fragile X syndrome.


  1. “Blepharochalasis: Symptoms, Causes, and Treatment” – Mayo Clinic Link:
  2. “Blepharochalasis: A Comprehensive Review” – Journal of Clinical and Aesthetic Dermatology Link:
  3. “Blepharochalasis: Diagnosis and Management” – American Academy of Ophthalmology Link:
  4. “Blepharochalasis: A Rare Cause of Eyelid Edema” – Dermatology Online Journal Link:
  5. “Blepharochalasis: A Case Report and Review of Literature” – Indian Journal of Ophthalmology Link:;year=2013;volume=61;issue=9;spage=535;epage=537;aulast=Prasad


Photo graph of Dr. Conlon operating with loops on.

Dr. M. Ronan Conlon started his career in the field of ophthalmology at the same time as the development of refractive eye surgery in Canada. In 1996, he brought laser technology to Canada from Germany, which allowed him to perform laser eye surgery before it was available in the United States. With the establishment of the Conlon Eye Institute, Dr. Conlon has performed more than 40,000 refractive procedures and has advanced his expertise in LASIK and refractive cataract surgery.


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