Eylea in a Syringe in front of Eye Chart

Eylea, a cutting-edge treatment for various eye conditions, has transformed the lives of countless patients. But what about the Eylea side effects that may come with this breakthrough treatment? This comprehensive guide will shed light on the uses and benefits of Eylea, its common side effects, serious complications, interactions with other medications, and tips for managing Eylea’s side effects. Read on to gain valuable insights and empower yourself with the knowledge to navigate Eylea’s treatment confidently.

Key Takeaways

  • Eylea is a biological medication used to treat and preserve vision in patients with eye conditions.
  • Common side effects of Eylea injections include blurry vision, eye pain, increased eye pressure and potentially serious complications such as retinal detachment or endophthalmitis.
  • Effective management of Eylea’s side effects requires clear communication between the patient and healthcare provider, regular monitoring of vision changes, and following the treatment plan provided by a doctor.

Eylea Uses and Benefits

A picture of a syringe with Eylea in it.

Eylea is a biologic medication skillfully designed to prevent leakage from blood vessels in the eye, ultimately treating various eye conditions. Administered through intravitreal injections, a healthcare professional carefully injects Eylea into the eye, usually once every 4 or 8 weeks on a long-term basis. But why do so many patients rely on Eylea to safeguard their vision?

Eylea’s effectiveness lies in its versatility, offering relief for a wide range of eye conditions. From retinal vein occlusion and diabetic macular edema to age-related macular degeneration, Eylea has made a significant impact in the lives of many patients, preserving their vision and improving their quality of life.

Retinal Vein Occlusion

Retinal vein occlusion is a condition that affects a person’s vision when a blood vessel in the retina becomes blocked, leading to blurred or distorted vision, and in some cases, permanent vision loss. With Eylea’s help, patients can experience improved vision by reducing swelling and leakage in the retina.

While the prevalence of retinal vein occlusion may appear low, impacting 0.5-2.0% for branch retinal vein occlusion (BRVO) and 0.1-0.2% for central retinal vein occlusion (CRVO), individuals with hypertension, diabetes, and other risk factors should not disregard this condition. Eylea enables patients to confidently tackle the challenges of retinal vein occlusion, thereby protecting their vision.

Diabetic Macular Edema

Another condition that Eylea effectively targets is diabetic macular edema, a complication of diabetes that can lead to vision loss. Eylea is a powerful weapon against this condition, providing a higher visual improvement level than other medications in clinical trials.

Eylea’s unique ability to impede the growth of new blood vessels and reduce fluid leakage helps reduce swelling and improve vision in individuals with diabetic macular edema. For those who suffer from this condition, Eylea offers much-needed hope and a more promising future.

Age-related macular degeneration (AMD) is a leading cause of vision loss in older adults, but Eylea’s proven efficacy in slowing down its progression has made it a game-changer in the field of ophthalmology.

Numerous studies and research support Eylea’s use in treating AMD, and the FDA has approved Eylea for treating wet AMD and other degenerative eye diseases. By choosing Eylea, patients with AMD can potentially preserve their vision and maintain their independence for years to come.

Eylea Coverage Saskatchewan

Aflibercept, marketed as Eylea, is approved for use in Saskatchewan to treat certain eye conditions. Based on the information available from the Saskatchewan Drug Plan, here are the specific conditions for which aflibercept is approved:

  1. Neovascular (Wet) Age-Related Macular Degeneration (AMD): Aflibercept is used to treat wet AMD, a condition characterized by the growth of abnormal blood vessels under the retina and macula that can leak fluid and cause damage leading to vision loss.
  2. Macular Edema Following Retinal Vein Occlusion (RVO): This includes macular edema following branch retinal vein occlusion (BRVO) and central retinal vein occlusion (CRVO), conditions that can lead to swelling and blurred vision due to blocked veins in the retina.
  3. Diabetic Macular Edema (DME): Aflibercept is used for DME treatment, which is swelling in the area of the retina called the macula due to leaking blood vessels in diabetic patients.
  4. Diabetic Retinopathy in Patients with Diabetic Macular Edema: It is also approved for treating diabetic retinopathy, a complication of diabetes that affects the eyes, specifically in cases where it has caused DME.

The coverage for aflibercept under the Saskatchewan Drug Plan may be subject to certain criteria being met, such as the severity of the condition, prior use of other treatments, and specific recommendations from a healthcare provider. The drug is typically provided under the Exception Drug Status (EDS) program, which means that a patient’s eligibility for coverage must be assessed and approved based on the program’s specific requirements.

To get the specific answer you’re looking for, you may want to contact the Drug Plan and Extended Benefits Branch of the Government of Saskatchewan directly at their phone number (306-787-3317) or email (dpeb@health.gov.sk.ca) for the most accurate and current information regarding the coverage of Eylea.

Eylea Injections in Saskatchewan – a Centralized Approach

In Saskatchewan, the administration of Eylea (aflibercept) injections is centralized in primarily two designated locations for patient care: the Eye Center at Saskatoon City Hospital and the Eye Center at Pasqua Hospital in Regina. This means that patients who require Eylea treatment must travel to one of these two facilities, regardless of where they live in the province.

The centralized approach to administering Eylea injections ensures that patients receive care from specialized providers and facilities equipped to deliver this specific treatment. However, it also means that some patients may face the burden of travel, which can involve significant distance and associated logistics, especially for those coming from rural or remote areas of Saskatchewan.

Despite the centralized administration of Eylea (aflibercept) injections at specific locations in Saskatchewan, it’s important to note that across Canada, the administration of Eylea and other anti-VEGF (Vascular Endothelial Growth Factor) injections is a procedure commonly performed in the offices of ophthalmologists. This broader access across the country allows patients to receive necessary treatments closer to home, reducing travel and making it more convenient to manage conditions such as wet age-related macular degeneration, macular edema following retinal vein occlusion, and diabetic macular edema.

The availability of these treatments in local ophthalmologists’ offices reflects the healthcare system’s adaptability and commitment to patient-centred care, contrasting the more centralized approach observed in Saskatchewan. This decentralized model of care for anti-VEGF therapy helps to address the needs of a diverse patient population and ensures that innovative and essential treatments are more accessible to those in need throughout Canada.

Common Side Effects of Eylea Injections

Side Effects of Eylea

As with any medical treatment, Eylea injections come with their own set of potential side effects. While most patients tolerate the injections well, some may experience common side effects such as blurry vision, eye pain, and increased eye pressure.

It is important to be aware of these side effects and monitor any changes in your condition, so you can promptly discuss them with your healthcare provider.

Blurry Vision

Blurry vision is a typical side effect of Eylea injections, usually resolving within a few days. Although it may be disconcerting to experience blurry vision after an injection, it is generally temporary and should dissipate without intervention.

However, if an extended period of blurred vision persists, it becomes vital to contact your doctor for further assessment and necessary intervention.

Eye Pain

Eye pain may occur after Eylea injections, ranging from mild discomfort to more severe pain. This side effect is generally mild and temporary, typically lasting less than one week. If you experience eye pain after the numbing drops have dissipated, consult your eye doctor for advice on a suitable pain reliever, if needed.

Increased Eye Pressure

Increased eye pressure is a common side effect of Eylea injections. This increase in pressure may cause discomfort or other symptoms and require your healthcare provider’s monitoring and management.

Should you observe a continual rise in eye pressure post-Eylea injections, you must notify your doctor, who will evaluate your symptoms and determine the right course of action. Swiftly addressing the increase in eye pressure can aid in averting potential complications and uphold the ongoing effectiveness of your treatment.

Serious Complications and Risks

Although Eylea injections are generally safe and well-tolerated, there are potentially serious complications and risks to be aware of, such as retinal detachment, endophthalmitis, and allergic reactions.

Recognizing the symptoms of these serious complications and seeking immediate medical assistance can help prevent long-term damage and ensure the best possible outcome for your vision.

Retinal Detachment

Retinal detachment is a rare but serious risk associated with Eylea injections, requiring immediate medical attention. The precise mechanism behind retinal detachment caused by Eylea injections is yet to be determined, but it is believed to involve either a direct tear from needle penetration through the retina or tractional forces induced with the injection.

Should you manifest symptoms of retinal detachment like:

  • heightened redness in the eye
  • eye pain
  • cataract
  • vitreous detachment
  • vitreous floaters

It becomes necessary to reach out to your doctor for assessment and treatment immediately.


Endophthalmitis is a severe eye infection that can occur after Eylea injections, necessitating prompt treatment to prevent vision loss. Symptoms of endophthalmitis include:

  • Ocular pain
  • Erythema
  • Decreased visual acuity
  • Conjunctival injection
  • Corneal edema
  • Abrupt and painless vision loss

If you experience any of these symptoms following an Eylea injection, it is crucial to seek immediate medical attention. Symptoms to watch out for include:

  • Severe eye pain
  • Decreased vision
  • Redness or swelling of the eye
  • Sensitivity to light
  • Floaters or spots in your vision
  • Increased eye discharge

Endophthalmitis is typically managed with intravitreal antibiotics, antibiotic eye drops, and/or vitreoretinal surgery, and prompt treatment, including an intravitreal injection, can help prevent permanent vision loss and other long-term effects.

Allergic Reactions

Allergic reactions to Eylea can range from mild to severe, and patients should be aware of potential symptoms. Typical symptoms associated with an allergic response to Eylea may include rash, itching, and swelling of the eyes, face, lips, tongue, or throat.

If you experience an allergic reaction to Eylea, it is imperative to seek immediate medical attention. Your doctor can evaluate your symptoms, determine the appropriate course of action, and adjust your treatment plan accordingly to ensure your safety and the effectiveness of your Eylea treatment.

Stroke Risk

Eylea (aflibercept) injections have a low incidence of stroke risk, but patients with pre-existing conditions such as hypertension or previous strokes may have a slightly increased risk. The benefits of treating retinal diseases typically outweigh this small potential risk. Patients must discuss their individual risk factors with their healthcare provider before receiving Eylea injections.

Interactions with Other Medications and Factors

Eylea might interact with other medications and lifestyle factors, thus it’s crucial to converse about these aspects with your healthcare provider to guarantee the optimal outcome for your treatment. Informing your doctor of all medications you are taking and any lifestyle factors that may impact your treatment can help minimize potential complications and maximize the benefits of Eylea.

Drug Interactions

Drug interactions with Eylea are possible, so it is crucial to inform your doctor of all medications you are taking, including:

  • Prescription medications
  • Over-the-counter medications
  • Vitamins
  • Supplements

Certain drug interactions may impede the efficacy of Eylea, potentially reducing its effectiveness.

For example, blood-thinning medications can interact with Eylea, possibly exacerbating bleeding associated with macular degeneration and increasing the risk of blood clots. By providing your doctor with a comprehensive list of medications, they can better assess your treatment plan and make any necessary adjustments to ensure the best possible outcome.

Lifestyle Factors

Lifestyle factors, such as alcohol consumption and pregnancy, as well as other factors, may impact Eylea’s effectiveness and safety. Research has indicated that alcohol consumption can have an effect on the anti-VEGF treatment response at the cellular level, potentially impacting the efficacy of Eylea treatment. It is advisable to consult with your doctor about the amount of alcohol consumption which is safe during Eylea treatment.

Additionally, the use of Eylea during pregnancy is contentious and not recommended due to limited data on its safety during pregnancy and the potential risk of harm to the fetus. It is essential to consult with your healthcare professional prior to using Eylea during pregnancy to ensure the safety of both you and your baby.

Tips for Managing Eylea Side Effects

Managing Eylea side effects involves communication with healthcare professionals, monitoring vision changes, and following your treatment plan. By taking an active role in your treatment, you can minimize side effects and maximize the benefits of Eylea, ensuring the best possible outcome for your vision and overall health.

Communication with Healthcare Professionals

Transparent dialogue with your healthcare provider is vital in managing Eylea side effects and addressing any concerns. Your healthcare provider plays an essential role in managing side effects, monitoring your progress, and making necessary adjustments to your treatment plan.

Conversing about your concerns and experiences with your healthcare provider can confirm that your treatment plan is customized to your distinctive needs, thereby reducing side effects and enhancing the benefits of Eylea.

Monitoring Vision Changes

Regularly monitoring vision changes can help detect potential complications early and ensure appropriate treatment. Tools such as the KeepSight Journal and home-based technologies can assist you in self-monitoring your vision, allowing you to identify any changes that may require medical attention.

It is important to regularly assess your vision and communicate any changes to your healthcare provider, who can evaluate your symptoms and make any necessary adjustments to your treatment plan.

Following Treatment Plan

Sticking to your prescribed treatment plan along with attending follow-up appointments can aid in reducing Eylea side effects and boosting its benefits. Your healthcare provider will create a personalized treatment plan, including the recommended dosage, administration schedule, and any additional treatments or medications.

By following your treatment plan and attending regular follow-up appointments, your healthcare provider can closely monitor your progress, assess any side effects or complications, and make necessary adjustments to ensure the best possible outcome for your vision.


In conclusion, Eylea is a powerful and versatile treatment for various eye conditions, offering hope and improved vision to countless patients. While side effects and potential complications exist, by staying informed, communicating with your healthcare provider, and actively managing your treatment, you can minimize potential risks and maximize the benefits of Eylea. Take control of your vision and embrace the life-changing possibilities that Eylea can offer.


  1. Risk of Endophthalmitis following Intravitreal Anti–Vascular Endothelial Growth Factor Injections in an Office Setting – American Journal of Ophthalmology
  2. Endophthalmitis after Intravitreal Anti–Vascular Endothelial Growth Factor Injections in an Office Setting – American Journal of Ophthalmology
  3. Acute intraocular inflammation after intravitreous injections of aflibercept – Clinical Ophthalmology
  4. Intraocular inflammation following intravitreal injections of aflibercept for treatment of neovascular age-related macular degeneration – Clinical Ophthalmology
  5. Rhegmatogenous retinal detachment after intravitreal aflibercept injection – Canadian Journal of Ophthalmology
  6. Acute sterile endophthalmitis following intravitreal aflibercept: a case series – Clinical Ophthalmology
  7. Retinal pigment epithelial tears after intravitreal aflibercept injection for neovascular age-related macular degeneration – Clinical Ophthalmology
  8. Retinal detachment after aflibercept therapy for age-related macular degeneration – Ophthalmology
  9. Risk of thromboembolic events in patients with exudative age-related macular degeneration treated with intravitreal bevacizumab versus ranibizumab – Ophthalmology
  10. Intravitreal aflibercept injection-related uveitis – Clinical Ophthalmology
Photo graph of Dr. Conlon operating with loops on.

Dr. M. Ronan Conlon started his career in the field of ophthalmology at the same time as the development of refractive eye surgery in Canada. In 1996, he brought laser technology to Canada from Germany, which allowed him to perform laser eye surgery before it was available in the United States. With the establishment of the Conlon Eye Institute, Dr. Conlon has performed more than 40,000 refractive procedures and has advanced his expertise in LASIK and refractive cataract surgery.

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